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- Title
Marine Bioactive Compounds with Functional Role in Immunity and Food Allergy.
- Authors
Abril, Ana G.; Carrera, Mónica; Pazos, Manuel
- Abstract
Food allergy, referred to as the atypical physiological overreaction of the immune system after exposure to specific food components, is considered one of the major concerns in food safety. The prevalence of this emerging worldwide problem has been increasing during the last decades, especially in industrialized countries, being estimated to affect 6–8% of young children and about 2–4% of adults. Marine organisms are an important source of bioactive substances with the potential to functionally improve the immune system, reduce food allergy sensitization and development, and even have an anti-allergic action in food allergy. The present investigation aims to be a comprehensive report of marine bioactive compounds with verified actions to improve food allergy and identified mechanisms of actions rather than be an exhaustive compilation of all investigations searching beneficial effects of marine compounds in FA. Particularly, this research highlights the capacity of bioactive components extracted from marine microbial, animal, algae, and microalgae sources, such as n-3 long-chain polyunsaturated fatty acids (LC-PUFA), polysaccharide, oligosaccharide, chondroitin, vitamin D, peptides, pigments, and polyphenols, to regulate the immune system, epigenetic regulation, inflammation, and gut dysbiosis that are essential factors in the sensitization and effector phases of food allergy. In conclusion, the marine ecosystem is an excellent source to provide foods with the capacity to improve the hypersensitivity induced against specific food allergens and also bioactive compounds with a potential pharmacological aptitude to be applied as anti-allergenic in food allergy.
- Subjects
FOOD safety; UNSATURATED fatty acids; CHONDROITIN; EPIGENOMICS; BIOLOGICAL products; FOOD allergy; FISHES; POLYSACCHARIDES; PEPTIDES; INFLAMMATION; IMMUNITY; MARINE animals; OLIGOSACCHARIDES; VITAMIN D; POLYPHENOLS
- Publication
Nutrients, 2024, Vol 16, Issue 16, p2592
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16162592