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- Title
Functional and Molecular Aspects of Voltage-Gated K<sup>+</sup> Channel β Subunits.
- Authors
PONGS, OLAF; LEICHER, THORSTEN; BERGER, MICHAELA; ROEPER, JOCHEN; BÄHRING, ROBERT; WRAY, DENNIS; GIESE, KARL PETER; SILVA, ALCINO J.; STORM, JOHAN F.
- Abstract
ABSTRACT: Voltage-gated potassium channels (Kv) of the Shaker-related superfamily are assembled from membrane-integrated α subunits and auxiliary β subunits. The β subunits may increase Kv channel surface expression and/or confer A-type behavior to noninactivating Kv channels in heterologous expression systems. The interaction of Kvα and Kvβ subunits depends on the presence or absence of several domains including the amino-terminal N-type inactivating and NIP domains and the Kvα and Kvβ binding domains. Loss of function of Kvβ1.1 subunits leads to a reduction of A-type Kv channel activity in hippocampal and striatal neurons of knock-out mice. This reduction may be correlated with altered cognition and motor control in the knock-out mice.
- Publication
Annals of the New York Academy of Sciences, 1999, Vol 868, Issue 1, p344
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.1999.tb11296.x