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- Title
MIP-esterase/Tyrosinase Combinations for Paracetamol and Phenacetin.
- Authors
Yarman, Aysu; Scheller, Frieder W.
- Abstract
A new electrochemical MIP sensor for the most frequently used drug paracetamol (PAR) was prepared by electropolymerization of mixtures containing the template molecule and the functional monomers o-phenylenediamine, resorcinol and aniline. The imprinting factor of 12 reflects the effective target binding to the MIP as compared with the non-imprinted electropolymer. Combination of the MIP with a nonspecific esterase allows the measurement of phenacetin - another analgesic drug. In the second approach the PAR containing sample solution was pretreated with tyrosinase in order to prevent electrochemical interferences by ascorbic acid and uric acid. Interference-free indication at a very low electrode potential without fouling of the electrode surface was achieved with the o-phenylenediamine: resorcinol-based MIP.
- Subjects
ACETAMINOPHEN; PHENACETIN; ELECTROCHEMICAL sensors; IMPRINTED polymers; ESTERASES; PHENOL oxidase; ELECTROPOLYMERIZATION
- Publication
Electroanalysis, 2016, Vol 28, Issue 9, p2222
- ISSN
1040-0397
- Publication type
Article
- DOI
10.1002/elan.201600042