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- Title
Electrochemically Enabled, Nickel-Catalyzed Amination.
- Authors
Li, Chao; Kawamata, Yu; Nakamura, Hugh; Vantourout, Julien C.; Liu, Zhiqing; Hou, Qinglong; Bao, Denghui; Starr, Jeremy T.; Chen, Jinshan; Yan, Ming; Baran, Phil S.
- Abstract
Along with amide bond formation, Suzuki cross-coupling, and reductive amination, the Buchwald-Hartwig-Ullmann-type amination of aryl halides stands as one of the most employed reactions in modern medicinal chemistry. The work herein demonstrates the potential of utilizing electrochemistry to provide a complementary avenue to access such critical bonds using an inexpensive nickel catalyst under mild reaction conditions. Of note is the scalability, functional-group tolerance, rapid rate, and the ability to employ a variety of aryl donors (Ar−Cl, Ar−Br, Ar−I, Ar−OTf), amine types (primary and secondary), and even alternative X−H donors (alcohols and amides).
- Subjects
NICKEL; ELECTROCHEMICAL analysis; HALIDES; ELECTROCHEMISTRY; CATALYSTS
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 42, p13268
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201707906