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- Title
Nanoscale Metal-Organic Layers for Deeply Penetrating X-ray-Induced Photodynamic Therapy.
- Authors
Lan, Guangxu; Ni, Kaiyuan; Xu, Ruoyu; Lu, Kuangda; Lin, Zekai; Chan, Christina; Lin, Wenbin
- Abstract
We report the rational design of metal-organic layers (MOLs) that are built from [Hf6O4(OH)4(HCO2)6] secondary building units (SBUs) and Ir[bpy(ppy)2]+- or [Ru(bpy)3]2+-derived tricarboxylate ligands (Hf-BPY-Ir or Hf-BPY-Ru; bpy=2,2′-bipyridine, ppy=2-phenylpyridine) and their applications in X-ray-induced photodynamic therapy (X-PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X-rays and transfer energy to Ir[bpy(ppy)2]+ or [Ru(bpy)3]2+ moieties to induce PDT by generating reactive oxygen species (ROS). The ability of X-rays to penetrate deeply into tissue and efficient ROS diffusion through ultrathin 2D MOLs (ca. 1.2 nm) enable highly effective X-PDT to afford superb anticancer efficacy.
- Subjects
PHOTODYNAMIC therapy; REACTIVE oxygen species; THIN films; PHOTOSENSITIZERS; NANOCHEMISTRY
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 40, p12270
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201704828