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- Title
Arsenic toxicity and epimutagenecity: the new LINEage.
- Authors
Paul, Somnath; Bhattacharjee, Pritha; Giri, Ashok
- Abstract
Global methylation pattern regulates the normal functioning of a cell. Research have shown arsenic alter these methylation landscapes within the genome leading to aberrant gene expression and inducts various pathophysiological outcomes. Long interspersed nuclear elements (LINE-1) normally remains inert due to heavy methylation of it's promoters, time and various environmental insults, they lose these methylation signatures and begin retro-transposition that has been associated with genomic instability and cancerous outcomes. Of the various high throughput technologies available to detect global methylation profile, development of LINE-1 methylation index shall provide a cost effect-screening tool to detect epimutagenic events in the wake of toxic exposure in a large number of individuals. In the present review, we tried to discuss the state of research and whether LINE-1 methylation can be considered as a potent epigenetic signature for arsenic toxicity.
- Subjects
METHYLATION; GENE expression; EPIGENETICS; PATHOLOGICAL physiology; GENETIC mutation
- Publication
BioMetals, 2017, Vol 30, Issue 4, p505
- ISSN
0966-0844
- Publication type
Article
- DOI
10.1007/s10534-017-0021-2