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- Title
The Impact of Urine-Sample HPV Testing on the Effectiveness of Screening for Cervical Cancer: An Umbrella Review.
- Authors
Miazga, Wojciech; Tatara, Tomasz; Wnuk, Katarzyna; Gujski, Mariusz; Pinkas, Jarosław; Religioni, Urszula
- Abstract
Simple Summary: Our purpose was to assess the impact of urine-sample HPV (human papillomavirus) testing on the effectiveness of screening for cervical cancer. We also assessed the acceptability of the self-collection of urine samples for HPV screening tests. Our analysis took into account research results published in systematic reviews of the available literature on the topic under study. Of the 1869 articles found in this area, we included 5 studies that met the criteria we assessed. We discovered that the sensitivity and specificity for the detection of any HPV in first-void urine samples were 87% [95% CI: (0.74; 0.94)] and 89% [95% CI: (0.81; 0.93)]. Moreover, participants in the analyzed studies had indicated that they felt comfortable with urine testing. We therefore conclude that the detection of HPV infection in first-void urine samples may have great diagnostic significance. The use of this method in commonly available screening tests could significantly increase patients' willingness to participate in research. Background: The aim of the study was to evaluate the impact of urine-sample HPV (human papillomavirus) testing on the effectiveness of screening for cervical cancer. Methods: The analysis was based on the results of a systematic review. Secondary studies were searched in the following medical databases: Medline, Embase, and the Cochrane Library. The results of the statistical tests presented in the article originate from research conducted by the authors of the included articles. Results: From a total of 1869 citations, 5 studies were included in this review. Sensitivity and specificity for the detection of any HPV from first-void urine samples were 87% [95% CI: (0.74; 0.94)] and 89% [95% CI: (0.81; 0.93)], respectively. Moreover, participants in the analyzed studies had indicated that they felt comfortable with urine testing. Conclusions: The development of methods to detect HPV infection in first-void urine samples and the application of this sampling method in widely available screening tests could significantly increase patients' willingness to participate in testing.
- Subjects
PAPILLOMAVIRUS disease diagnosis; MEDICAL information storage &; retrieval systems; CERVIX uteri tumors; SYSTEMATIC reviews; MEDLINE; URINALYSIS; MEDICAL databases; MEDICAL screening; URINE collection &; preservation; SENSITIVITY &; specificity (Statistics)
- Publication
Cancers, 2024, Vol 16, Issue 12, p2244
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16122244