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- Title
Effects of oral 5-hydroxytryptophan on a standardized planning task: insight into possible dopamine/serotonin interactions in the forebrain.
- Authors
Gendle, Mathew H.; Young, Erica L.; Romano, Alexandra C.
- Abstract
Objective Several studies have suggested that exogenous administration of the serotonin precursor 5-hydroxytryptophan (5-HTP) can result in the ectopic production of serotonin in dopaminergic neurons and a concomitant reduction in dopamine release. This study tested this hypothesis using the Tower of London (TOL), a test of planning and executive control that is sensitive to changes in forebrain dopamine activity, but insensitive to alterations in serotonin. Methods A sample of 68 undergraduates participated, and each received either three 50-mg 5-HTP capsules or placebos, and completed the TOL following a set absorption period. Results 5-HTP significantly lengthened the average time needed to complete each of the 10 trials of the TOL. 5-HTP did not affect accuracy on this task. Conclusions Oral exogenous 5-HTP disrupts dopaminergic function in the human forebrain. Copyright © 2013 John Wiley & Sons, Ltd.
- Subjects
HYDROXYTRYPTOPHAN; SEROTONIN; DOPAMINERGIC neurons; DOPAMINE; PROSENCEPHALON; APPETITE depressants; ANTIDEPRESSANTS; THERAPEUTICS
- Publication
Human Psychopharmacology: Clinical & Experimental, 2013, Vol 28, Issue 3, p270
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.2314