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- Title
Serum Mac-2-binding protein (M2BPGi) as a marker of chronological liver fibrosis in biliary atresia patients with cirrhosis.
- Authors
Ueno, Takehisa; Kodama, Tasuku; Noguchi, Yuki; Nomura, Motonari; Saka, Ryuta; Takama, Yuichi; Tazuke, Yuko; Bessho, Kazuhiko; Okuyama, Hiroomi
- Abstract
<bold>Purpose: </bold>Biliary atresia (BA) is characterized by progressive liver fibrosis, but it is difficult to assess the progression after the patient develops cirrhosis. Mac-2-binding protein glycosylation isomer (M2BPGi) is a new marker for hepatic fibrosis. We examined the chronological changes in M2BPGi levels in BA patients with cirrhosis.<bold>Methods: </bold>Patients with cirrhosis were selected from among pediatric BA patients who had their native livers. Serum M2BPGi levels and Child-Pugh classification were evaluated. A total of 11 pediatric BA patients with cirrhosis were recruited.<bold>Results: </bold>Initial M2BPGi level after diagnosis of liver cirrhosis based on liver biopsy was on average 3.4, and the most recent M2BPGi level under observation was on average 4.3. The follow-up period from the initial M2BPGi measurement averaged 22.6 months. The ratio of the initial and most recent values (M2BPGi ratio) was on average 1.3 (0.5-2.4). Three cases with improved fibrosis (M2BPGi ratio < 1.0) remained in Child A, as did six cases (1.0 ≤ M2BPGi ratio < 2.0), but two cases with marked fibrosis progression (2.0 ≤ M2BPGi ratio) advanced to decompensated cirrhosis Child B.<bold>Conclusion: </bold>M2BPGi is useful as a prognostic factor for BA patients with liver cirrhosis. In addition, fibrosis improved even after the development of cirrhosis.
- Subjects
BILIARY atresia; BLOOD proteins; CIRRHOSIS of the liver; FIBROSIS; HEPATIC fibrosis
- Publication
Pediatric Surgery International, 2019, Vol 35, Issue 10, p1065
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-019-04535-9