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- Title
Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative.
- Authors
Gersing, Alexandra; Schwaiger, Benedikt; Heilmeier, Ursula; Joseph, Gabby; Facchetti, Luca; Kretzschmar, Martin; Lynch, John; McCulloch, Charles; Nevitt, Michael; Steinbach, Lynne; Link, Thomas; Gersing, Alexandra S; Schwaiger, Benedikt J; Joseph, Gabby B; Lynch, John A; McCulloch, Charles E; Nevitt, Michael C; Steinbach, Lynne S; Link, Thomas M
- Abstract
<bold>Objectives: </bold>To evaluate the ability of different MRI sequences to detect chondrocalcinosis within knee cartilage and menisci, and to analyze the association with joint degeneration.<bold>Methods: </bold>Subjects with radiographic knee chondrocalcinosis (n = 90, age 67.7 ± 7.3 years, 50 women) were selected from the Osteoarthritis Initiative and matched to controls without radiographic chondrocalcinosis (n = 90). Visualization of calcium-containing crystals (CaC) was compared between 3D T1-weighted gradient-echo (T1GE), 3D dual echo steady-state (DESS), 2D intermediate-weighted (IW), and proton density (PD)-weighted fast spin-echo (FSE) sequences obtained with 3T MRI and correlated with a semiquantitative CaC score obtained from radiographs. Structural abnormalities were assessed using Whole-Organ MRI Score (WORMS) and logistic regression models were used to compare cartilage compartments with and without CaC.<bold>Results: </bold>Correlations between CaC counts of MRI sequences and degree of radiographic calcifications were highest for GE (rT1GE = 0.73, P < 0.001; rDESS = 0.68, P < 0.001) compared to other sequences (P > 0.05). Meniscus WORMS was significantly higher in subjects with chondrocalcinosis compared to controls (P = 0.005). Cartilage defects were significantly more frequent in compartments with CaC than without (patella: P = 0.006; lateral tibia: P < 0.001; lateral femur condyle: P = 0.017).<bold>Conclusions: </bold>Gradient-echo sequences were most useful for the detection of chondrocalcinosis and presence of CaC was associated with higher prevalence of cartilage and meniscal damage.<bold>Key Points: </bold>• Magnetic resonance imaging is useful for assessing burden of calcium-containing crystals (CaC). • Gradient-echo sequences are superior to fast spin echo sequences for CaC imaging. • Presence of CaC is associated with meniscus and cartilage degradation.
- Subjects
CHONDROCALCINOSIS; ARTHRITIS; CALCINOSIS; CARTILAGE; DEGENERATION (Pathology); CARTILAGE diseases; COMPARATIVE studies; KNEE; KNEE diseases; LONGITUDINAL method; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; OSTEOARTHRITIS; PATELLA; RADIOGRAPHY; RESEARCH; RESEARCH funding; EVALUATION research; RESEARCH bias; DISEASE complications; DIAGNOSIS
- Publication
European Radiology, 2017, Vol 27, Issue 6, p2497
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4608-8