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- Title
Peripheral arterial thrombosis induced by chemotherapy in ovarian carcinoma coexisted with endometrial carcinoma.
- Authors
Hida, Kazuhide; Ikeda, Shun-ichi; Shimizu, Shoko; Yoshikata, Remi; Orito, Seiya; Tatsuduki, Ayano; Ohta, Hiroaki
- Abstract
Most patients with peripheral arterial occlusion have underlying atherosclerosis. Peripheral arterial thrombosis induced by chemotherapy in gynecological malignancies is rare. A 60-year-old woman was diagnosed with ovarian carcinoma coexisting with endometrial carcinoma after surgical histopathological examination. Chemotherapy was started on postoperative day 11. On day 2 of chemotherapy, she developed bilateral lower extremity cyanosis. Thrombocytopenia due to chemotherapy was diagnosed and treated with repeated platelet transfusions. Anticoagulant therapy was also continued. However, the patient worsened steadily and died of liver dysfunction due to multiple liver metastases. Although arterial thrombosis induced by chemotherapy is rare, it is important for physicians to consider this possibility in the course of treatment with cytotoxic agents because this complication has serious health implications.
- Subjects
ARTERIAL occlusions; BLOOD vessels; ATHEROSCLEROSIS; THROMBOSIS; BLOOD coagulation
- Publication
Archives of Gynecology & Obstetrics, 2007, Vol 275, Issue 1, p63
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-006-0193-4