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- Title
Resting heart rate and risk of metabolic syndrome in adults: a dose-response meta-analysis of observational studies.
- Authors
Liu, Xuejiao; Luo, Xinping; Liu, Yu; Sun, Xizhuo; Han, Chengyi; Zhang, Lu; Wang, Bingyuan; Ren, Yongcheng; Zhao, Yang; Zhang, Dongdong; Hu, Dongsheng; Zhang, Ming
- Abstract
The magnitude of the risk of metabolic syndrome (MetS) with increased resting heart rate (RHR) has been inconsistently reported in some observational studies, and whether a dose-response relationship exists between RHR and MetS is unclear. We performed a meta-analysis including dose-response analysis to quantitatively evaluate this association in adults. We searched PubMed, Web of Knowledge, China National Knowledge Infrastructure, and WanFang databases for articles published up to April 2, 2016. A random-effects model was used to pool relative risks (RRs) and 95% confidence intervals (CIs); restricted cubic spline function was used to assess the dose-response relationship. Seven prospective cohort studies and 10 cross-sectional studies with a total of 169,786 participants were included. The pooled RR was 2.10 (95% CI 1.80-2.46, I = 79.8%, n = 13) for the highest versus reference RHR category and 1.28 (95% CI 1.23-1.34, I = 87.7%, n = 15) for each 10 beats per minute (bpm) increment in RHR. We found no evidence of a nonlinear dose-response association between RHR and MetS ( P = 0.201). The relationship was consistent in most subgroup analyses and robust on sensitivity analysis. No significant publication bias was observed. This meta-analysis suggests that risk of MetS may be increased with elevated RHR.
- Subjects
HEART beat; METABOLIC syndrome risk factors; INSULIN resistance; METABOLIC disorders; META-analysis
- Publication
Acta Diabetologica, 2017, Vol 54, Issue 3, p223
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-016-0942-1