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- Title
Erythrocyte glutathione transferase activity: a possible early biomarker for blood toxicity in uremic diabetic patients.
- Authors
Noce, Annalisa; Fabrini, Raffaele; Dessì, Mariarita; Bocedi, Alessio; Santini, Silvia; Rovella, Valentina; Pastore, Anna; Tesauro, Manfredi; Bernardini, Sergio; Daniele, Nicola; Ricci, Giorgio
- Abstract
Erythrocyte glutathione transferase (e-GST) displays increased activity in patients with renal damage and positive correlation with homocysteine (Hcy) in patients under maintenance hemodialysis. Here, we determined e-GST, Hcy, and erythrocyte catalase (e-CAT) in 328 patients affected by type 2 diabetes mellitus (T2DM), 61 diabetic non-nephropathic patients and 267 affected by diabetes and by chronic kidney disease (CKD) under conservative therapy subdivided into four stages according to K-DOQI lines. e-GST activity was significantly higher in all T2DM patients compared to the control group (7.90 ± 0.26 vs. 5.6 ± 0.4 U/g), and we observed an enhanced activity in all subgroups of CKD diabetic patients. No significant correlation or increase has been found for e-CAT in all patients tested. Mean Hcy in diabetic patients is higher than that in healthy subjects (33.42 ± 1.23 vs. 13.6 ± 0.8 μM), and Hcy increases in relation to the CKD stage. As expected, a significant correlation was found between e-GST and Hcy levels. These findings suggest that e-GST hyperactivity is not caused directly by diabetes but by its consequent renal damage. e-GST, as well as Hcy, may represent an early biomarker of renal failure.
- Subjects
GLUTATHIONE transferase; BIOMARKERS; KIDNEY failure; HOMOCYSTEINE; HEMODIALYSIS patients; TYPE 2 diabetes
- Publication
Acta Diabetologica, 2014, Vol 51, Issue 2, p219
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-013-0497-3