We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Assessment of insulin sensitivity ( S) and glucose effectiveness ( S) from a standardized hyperglucidic breakfast test in type 2 diabetics exhibiting various levels of insulin resistance.
- Authors
Brun, Jean-Frédéric; Ghanassia, Edouard; Fédou, Christine; Bordenave, Sylvain; Raynaud de Mauverger, Eric; Mercier, Jacques
- Abstract
We investigated the measurement of insulin sensitivity ( S) with a standardized hyperglucidic breakfast (SHB) compared to minimal model analysis of an intravenous glucose tolerance test ( S-IVGTT) in 17 patients clinically referred as type 2 diabetics, not yet treated by insulin, and representing a wide range of body mass index and S. To classify the patients, ten meal-tolerance test-based calculations of S (MTT- S) were compared to S-IVGTT, and their reference values and distribution were measured on a separate sample of 200 control SHBs and 209 control IVGTTs. Eight MTT-S indices exhibit significant correlations with S-IVGTT: Mari's OGIS index, BIGTT-SI|, BIGTT-SI| 1/ G I, Caumo's oral minimal model (OMM), Sluiter's index 'A' = 10/( I· G), Matsuda's composite index given by the formula ISIcomp = 10/( I G I G), S = 1/ I G I G with r ranging between 0,53 and 0,28. S-IVGTT and S-MTT exhibited in the lower range a very different (non-normal) pattern of distribution and thus the cutoff value for defining insulin resistance varied among indices. With such cutoffs, S-MTT < 6.3 min/(μU/ml) 10 with Caumo's OMM was the best predictor of insulin resistance defined as S-IVGTT < 2 min/(μU/ml) 10. Other indices, including OGIS and BIGTT, resulted in more misclassifications of patients. HOMA-IR and QUICKI were poor predictors. The formula $$ S_{\rm G}=2.921\,{\text{e}}^{-0.185({\text{G}}_{60}-{\text{G}}_{0})}$$ satisfactorily predicts IVGTT-derived glucose effectiveness in type 2 diabetics. Thus, SHB appears suitable for the measurement of S and S in type 2 diabetics, and the OMM seems to provide the most accurate SHB-derived index in this population.
- Subjects
INSULIN resistance; PEOPLE with diabetes; GLUCOSE; GLUCOSE tolerance tests
- Publication
Acta Diabetologica, 2013, Vol 50, Issue 2, p143
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-010-0232-2