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- Title
Chlamydia pneumoniae accompanied by inflammation is associated with the progression of atherosclerosis in CAPD patients: a prospective study for 3 years.
- Authors
Dong Ki Kim; Hyun Jin Kim; Seung Hyeok Han; Jung Eun Lee; Sung Jin Moon; Beom Seok Kim; Shin-Wook Kang; Kyu Hun Choi; Ho Yung Lee; Dae-Suk Han
- Abstract
Background. The causes of accelerated atherosclerosis in end-stage renal disease (ESRD) patients are unknown, although recent studies have suggested that Chlamydia pneumoniae (Cp) infection and inflammation might be contributing factors. We aimed to evaluate the association of carotid atherosclerosis progression with Cp infection and inflammation in patients undergoing peritoneal dialysis (PD). Methods. This is a prospective observational study. A total of 52 non-diabetic prevalent PD patients were included. The intima-media thickness of a common carotid artery (CCA-IMT) was measured at baseline and after 36 months by B-mode ultrasonography. Serum antibodies to Cp and inflammatory markers were obtained at the time of initial measurement of the CCA-IMT. Results. CCA-IMT progressors (ΔCCA-IMT ≥ 0.015 mm/year) had a higher prevalence of seropositivity for Cp IgA antibody, a higher level of Cp IgA antibodies indices, log IL-(interleukin-)6, and intercellular adhesion molecule-1 (ICAM-1) compared to the non-progressors (ΔCCA-IMT Conclusions. Our data showed that Cp and inflammation were significant risk factors of CCA-IMT change in PD patients. This study strengthens evidence that Cp is involved in the pathogenesis of atherosclerosis and also suggests that the effect of Cp infection under high inflammatory status might be a risk factor for progression of atherosclerosis.
- Subjects
CHLAMYDOPHILA pneumoniae; ATHEROSCLEROSIS; CHRONIC kidney failure; PERITONEAL dialysis
- Publication
Nephrology Dialysis Transplantation, 2008, Vol 23, Issue 3, p1011
- ISSN
0931-0509
- Publication type
Article