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- Title
Efficacy of cefmenoxime in experimental group B streptococcal bacteraemia and meningitis.
- Authors
Kim, Kwang Sik
- Abstract
Cefmenoxime, a new semisynthetic cephalosporin, was evaluated and in comparison with penicillin G against a type III group B streptococcal strain. , the minimal inhibitory and minimal bactericidal concentrations of the two drugs were very close (≤2 dilutions). studies using experimental bacteraemia and meningitis in newborn rats revealed that despite similar drug levels, cefmenoxime had significantly greater bactericidal titres in blood at 6–7 h after administration and bacterial clearance from blood was significantly faster with cefmenoxime than with penicillin G at the end of one day of treatment. In addition, all animals with cefmenoxime therapy had bactericidal titres in cerebrospinal fluid ≥ 1:8 at 1–2 h after administration, whereas most (67%) animals receiving penicillin G had titres < 1:8. However, overall efficacy of cefmenoxime was similar to that of penicillin G. These findings suggest that cefmenoxime may be an effective alternative against group B streptococcal infection.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1986, Vol 17, Issue 2, p239
- ISSN
0305-7453
- Publication type
Article