Back to matchesWe found a matchYour institution may have access to this item. Find your institution then sign in to continue.TitleThe Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat ProteinAuthorsXiong, Xin; Hao, Yan; Sun, Kan; Li, Jiaxing; Li, Xia; Mishra, Bibhudatta; Soppina, Pushpanjali; Wu, Chunlai; Hume, Richard I.; Collins, Catherine A.AbstractHighwire, a conserved axonal E3 ubiquitin ligase, regulates the initiation of axonal degeneration after injury in Drosophila by regulating the levels of the NAD+ biosynthetic enzyme, Nmnat, and the Wnd kinase.SubjectsUBIQUITIN ligases; AXONAL transport; LABORATORY mice; NEURODEGENERATION; DROSOPHILAPublicationPLoS Biology, 2012, Vol 10, Issue 12, p1ISSN1544-9173Publication typeArticleDOI10.1371/journal.pbio.1001440