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- Title
Microbial transformation of cannabinoids. Part 3: Major metabolites of (3 R, 4 R)-Δ<sup>1</sup>-tetrahydrocannabinol.
- Authors
Binder, Michael; Popp, Astrid
- Abstract
The metabolic transformations of the psychotropic cannabinoid (3 R, 4 R)-Δ1-tetrahydrocannabinol (5) (=Δ1-THC) by cultures of Fusarium Nivale, Gibberella fujikuroi (both Ascomycetes) and Thamnidium elegans (Phycomycetes) were investigated. A number of metaboilites, 1-4 and 6-9 were isolated from the incubations, partly purified and their structures elucidated by combined gas chromatography/mass spectrometry. Four of these metabolites, 1″-hydroxy-Δ1-THC (4) 2″-hydroxy-β1-THC (1) 6Δ-hydroxy-ζ1-THC (8) and 2″,6Δ-dihydroxy-Δ1-THC (9) so far have not been reported as microbial transformation products of 5.
- Publication
Helvetica Chimica Acta, 1980, Vol 63, Issue 8, p2515
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19800630846