We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Total Synthesis of Indole and Dihydroindole Alkaloids. VIII. Studies on the synthesis of bisindole alkaloids in the vinblastine-vincristine series. The chloroindolenine approach.
- Authors
Kutney, James P.; Beck, John; Bylsma, Feike; Cook, James; Cretney, Walter J.; Fuji, Kaoru; Imhof, René; Treasurywala, Adi M.
- Abstract
Studies on the syntheses of 18′-epi-4′-deoxo-4′-epivinblastine (IX, R = CO2CH3; R1 = H), 18′-decarbomethoxy-18′-epi-4′-deoxo-4′-epivinblastine (IX, R = R1 = H) and related analogues are described. The synthetic method employs a coupling reaction involving chloroindolenine derivatives of the cleavamine series (for example, III) with vindoline (V) under acidic conditions. The complete structures, including absolute configuration, of the resulting dimers are established by a combination of chemical and spectroscopic techniques, including X-ray analysis.
- Publication
Helvetica Chimica Acta, 1975, Vol 58, Issue 6, p1690
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19750580622