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- Title
Therapie asymptomatischer Karotisstenosen: Notwendige Klärung der Evidenz mit neuem SPACE-2-Design.
- Authors
Reiff, T.
- Abstract
Asymptomatic carotid artery stenosis may be treated with carotid endarterectomy (CEA), carotid artery stenting (CAS) or with best medical treatment (BMT) only. Definitive and evidence-based treatment recommendations for one of these options are currently not possible. Studies showing an advantage of CEA over BMT alone do not meet current standards from a pharmacological point of view. On the other hand, more recent data point to a further stroke risk reduction using BMT according to current standards. Studies on carotid artery stenting as a third alternative treatment are partially insufficient, especially when comparing CAS with BMT. Initiated in 2009, the randomized, controlled, multicenter SPACE-2 trial is intended to answer the question about the best treatment option of asymptomatic carotid artery stenosis; however, to increase recruitment rates as a condition for the successful completion of this important study, the trial design had to be modified.
- Subjects
CAROTID artery stenosis; CAROTID endarterectomy; SURGICAL stents; PHARMACEUTICAL research; STROKE risk factors; THERAPEUTICS
- Publication
Der Nervenarzt, 2013, Vol 84, Issue 12, p1504
- ISSN
0028-2804
- Publication type
Article
- DOI
10.1007/s00115-013-3906-5