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- Title
ANÁLISE DO PADRÃO DE METILAÇÃO NO USO DE MARCADORES EPIGENÉTICOS NA CIÊNCIA FORENSE.
- Authors
Victoria de Morais Born Ribeiro, Maria; Amorim Carvalho de Santana, Bianca Coelho; Leão Diniz, Danielle; da Silva Torres, Mariana; Chagas da Cruz Correia, Mariana; Montenegro de Pereira Campos, Rodrigo; Lima Barreto, Samara; Souza e Pinto, Ana Paula
- Abstract
INTRODUCTION: Forensic science represents the application of various scientific disciplines, such as medicine, chemistry, physics and biology to the sphere of criminal investigation. Thus, one of the forms of investigation to solve relevant forensic questions without an answer, that has been gaining more and more prominence, is the study of epigenetic variation, examining the profile of standard forensic DNA, mainly through DNA methylation. The present study aims to evaluate the analysis of DNA methylation pattern as an epigenetic marker in forensic science, present its main forms of application, discuss the role and importance in studies such as death circumstances and the postmortem interval. MATERIAL AND METHODS: This article is a systematic integrative review and had its research done in the Pubmed and VHL databases, looking for articles in Portuguese, English or Spanish published in the last 5 years. The descriptors used were "Epigenesis", "DNA methylation", "Forensic genetics" and "Postmortem", in different orders, with the Boolean operator AND between them. RESULT: The main results indicate that DNA methylation analysis is an essential technique for investigative processes, as it is an epigenetic screening factor.DISCUSSION: Today's superior technologies allow DNA methylation profiles to reveal information about how or when biological fluids were deposited during crime scenes. CONCLUSION: Provide identification of what biological tissue or fluid source the sample originated from, as well as provide age estimates, sex and phenotypic characteristics, determining specificities of biological material indispensable in Forensic Science.
- Subjects
FORENSIC genetics; DNA methylation; SEX (Biology); CRIMINAL investigation; DNA analysis; FORENSIC sciences
- Publication
Revista Foco (Interdisciplinary Studies Journal), 2023, Vol 16, Issue 7, p1
- ISSN
1981-223X
- Publication type
Article
- DOI
10.54751/revistafoco.v16n7-090