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- Title
Monkeying around with HIV vaccines: using rhesus macaques to define 'gatekeepers' for clinical trials.
- Authors
Shedlock, Devon J.; Silvestri, Guido; Weiner, David B.
- Abstract
Rhesus macaques are an important animal model for the study of human disease and the development of vaccines against HIV and AIDS. HIV vaccines have been benchmarked in rhesus macaque preclinical challenge studies using chimeric viruses made up of parts of HIV and simian immunodeficency viruses. However, the lack of efficacy in a recent clinical trial calls for a re-evaluation of the scientific assumptions regarding the predictive value of using data generated from rhesus macaques as a 'gatekeeper' for the advancement of candidate vaccines into the clinic. In this context, there is significant consensus among HIV vaccinologists that next-generation HIV vaccines must generate 'better' immunity in rhesus macaques than clinically unsuccessful vaccines generated using validated assays. Defining better immunity is the core challenge of HIV vaccine development in this system and is the focus of this Review.
- Subjects
RHESUS monkeys; AIDS vaccines; INFORMATION resources management; HIV infections; SIMIAN viruses; CLINICAL trials
- Publication
Nature Reviews Immunology, 2009, Vol 9, Issue 10, p717
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2636