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- Title
Mast cell-dependent migration of effector CD8<sup>+</sup> T cells through production of leukotriene B<sub>4</sub>.
- Authors
Ott, Vanessa L.; Cambier, John C.; Kappler, John; Marrack, Philippa; Swanson, Bradley J.
- Abstract
Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.
- Subjects
T cells; INFLAMMATION; LEUCOCYTES; CD antigens; LYMPHOCYTES
- Publication
Nature Immunology, 2003, Vol 4, Issue 10, p974
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni971