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- Title
血清 SHBG 水平与妊娠期糖尿病胰岛素抵抗的关系研究.
- Authors
王喆; 张倩; 黎曼侬; 黎丽; 李季梅; 张凤
- Abstract
Objective: To study the relationship between sex hormone-binding globulin (SHBG) and insulin resistance in pregnant woman with gestational diabetes mellitus (GDM). Methods: 90 pregnant woman with gestational diabetes who were treated in our hospital from March 2015 to January 2016 were selected as the observation group, and 45 cases of healthy pregnant women were selected as the control group. The content of SHBG, insulin (INS), C peptide and free testosterone (FT) of two groups were detected by chemiluminescence method. Glycosylated glycosylated hemoglobin (HbA1c) was tested by hemoglobin meter testing, and the fasting blood glucose (FBG) were rested by biochemical analyzer. The insulin resistance (HOMA-IR) and sensitivity index (ISI) were calculated.The relationship of the indexes between two groups and the relationship between the indexes and the two exponents were analyzed.Results: The insulin levels of limosis and postprandial 2 h and 3 h in observation group were higher than the control group, the difference was statistically significant (P<0.05). The C peptide value of the observation group in 1 h and 2 h after meal were lower than the control group, while the C peptide value in 3 h after meal was higher than the control group, the differences were statistically significant (P<0.05). The levels of SHBG and ISI in observation group were lower than the control group, and the HOMA-IR, FT, FBG and HbA1c in observation group were higher than the control group, the differences were statistically significant (P<0.05). SHBG were negative correlated to FINS, C peptide, HOMA-IR, and which was positively correlated to ISI, the differences were statistically significant (P<0.05). Conclusion: The pregnant woman with GDM decreases with insulin resistance and sensitivity insulin, Serum SHBG levels are decreased and correlated with INS levels, IR and sensitivity. Detecting the serum level of SHBG can help to know the insulin resistance of GMD.
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 1, p251
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.02.038