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- Title
KRT17 promotes endometrial cancer cell migration as well as angiogenesis by regulating HIF-1a/VEGF pathway.
- Authors
Li Xu; Yanbo Liu; Ping Xu; Limei Zhang; Mo Li; Yang Zhang; Lu Peng; Fengxia Xue
- Abstract
Endometrial cancer (EC) is a common type malignant tumors in women. To combat this type of cancer, more effective treatments are still needed. EC cell growth and metastasis depend on angiogenesis. Keratin (KRT) is a family of proteins which are essential for hair formation. KRT17 affected a variety of cancers. Here, we reported that KRT17 expression was high in human EC. The depletion of KRT17 suppressed EC cell growth. We further showed the ablation of KRT17 led to the suppression of cell motility. Also, its depletion resulted in the inhibition of angiogenesis. We further demonstrated that KRT17 contributed to the progression of EC via regulating the HIF-1α/VEGF axis through a tumor growth assay in mice. In conclusion, KRT17 could serve as an EC target.
- Subjects
ENDOMETRIAL cancer; NEOVASCULARIZATION; KERATIN; CELL growth; METASTASIS
- Publication
European Journal of Gynaecological Oncology, 2023, Vol 44, Issue 3, p76
- ISSN
0392-2936
- Publication type
Article
- DOI
10.22514/ejgo.2023.041