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- Title
Oral S2-Ag85 DNA Vaccine Activated Intestinal Cell dsDNA and RNA Sensors to Promote the Presentation of Intestinal Antigen.
- Authors
Sheng, Dang; Xin, Sui; Dongxing, Wu; Shubo, Wen; Yang, Song; Zeliang, Chen; Jingbo, Zhai
- Abstract
<bold>Objective: </bold>To explore the molecular mechanism by which oral S2-Ag85DNA vaccines present intestinal antigens. The oral S2-Ag85 vaccine has been shown to protect the human body and effectively improve the titration of the vaccine by acting on intestinal mucosa cells and enhancing their immunogenicity.<bold>Method: </bold>Mice were immunized with the recombinant S2-Ag85 vaccine, and antibody secretion was then detected in the intestinal tissue. The molecular mechanisms of in vitro detection sensor molecules RIG-1, Pol III, and related conductor transductor molecules DAI, STING, AIM2, IRF3, and IRF7 were determined by separating intestinal IEC, DC, and IELC cells.<bold>Results: </bold>The S2-Ag85A vaccine was effective in activating dsDNA and RNA transduction pathways in intestinal cells and improving intestinal antigen presentation in mice.
- Subjects
DNA vaccines; VACCINE effectiveness; ANTIGEN presentation; INTESTINES; ORAL vaccines; HUMORAL immunity; VACCINES; RNA; BACTERIAL antigens; MICE; ANIMALS
- Publication
Journal of Immunology Research, 2022, p1
- ISSN
2314-8861
- Publication type
journal article
- DOI
10.1155/2022/7200379