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- Title
Effect of FK 506 Administered Topically versus Intramuscularly on Suppression of the Corneal Immune Reaction in Rats.
- Authors
Okada, Koji; Sakata, Hiroshi; Minamoto, Atushi; Fujihara, Megumu
- Abstract
The immunosuppressive effect of FK 506 on penetrating keratoplasty in rats was evaluated following intramuscular and topical administration. Implanted corneal grafts were inspected weekly by clinical evaluation for 3 weeks. Cytotoxic T lymphocyte (CTL) activity was measured in the spleen on postoperative day 21, and the grafts were examined histologically. A dose of FK 506, 0.1 mg/kg given intramuscularly, only moderately suppressed CTL activity and the graft failed. In contrast, doses of either 0.024 mg/day topically or 0.3 mg/kg intramuscularly suppressed CTL activity and the grafts remained intact. Results suggest that FK 506 administered topically would be effective in preventing failure of human corneal grafts. Copyright © 1996 S. Karger AG, Basel
- Publication
Ophthalmologica, 1996, Vol 210, Issue 3, p175
- ISSN
0030-3755
- Publication type
Article
- DOI
10.1159/000310702