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- Title
Myxobacteria of the Cystobacterineae Suborder Are Producers of New Vitamin K 2 Derived Myxoquinones.
- Authors
Panter, Fabian; Popoff, Alexander; Garcia, Ronald; Krug, Daniel; Müller, Rolf
- Abstract
Vitamin K is an essential, lipid soluble vitamin that plays an important role in the human blood coagulation cascade as well as in the life cycle of bacteria and plants. In this study, we report the isolation and structure elucidation of unprecedented polyhydroxylated menaquinone variants named myxoquinones that are produced by myxobacteria and structurally belong to the Vitamin K family. We analyze the occurrence of myxoquinones across an LC-MS data collection from myxobacterial extracts and shed light on the distribution of myxoquinone-type biosynthetic gene clusters among publicly available myxobacterial genomes. Our findings indicate that myxoquinones are specifically produced by strains of the Cystobacterineae suborder within myxobacteria. Furthermore, bioinformatic analysis of the matching gene clusters allowed us to propose a biosynthetic model for myxoquinone formation. Due to their increased water-solubility, the myxoquinones could be a suitable starting point for the development of a better bioavailable treatment of vitamin K deficiency.
- Subjects
VITAMIN K2; VITAMIN K; MYXOBACTERALES; PLANT life cycles; GENE clusters
- Publication
Microorganisms, 2022, Vol 10, Issue 3, p534
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms10030534