We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population.
- Authors
Wu, Vin-Cent; Huang, Kuo-How; Peng, Kang-Yung; Tsai, Yao-Chou; Wu, Che-Hsiung; Wang, Shuo-Meng; Yang, Shao-Yu; Lin, Lian-Yu; Chang, Chin-Chen; Lin, Yen-Hung; Lin, Shuei-Liong; Chu, Tzong-Shinn; Wu, Kwan-Dun
- Abstract
Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3 ± 12.3years) who received adrenalectomy, and were collected from the Taiwan PA investigator (TAIPAI) group. A high rate of somatic mutation in APA was found (n = 91, 61.5%); including mutations in KCNJ5 (n = 88, 59.5%), ATP1A1 (n = 2, 1.4%), and ATP2B3 (n = 1, 0.7%); however, no mutations in CACNA1D were identified. Mutation-carriers were younger (<0.001), had lower Cyst C (p = 0.042), pulse wave velocity (p = 0.027), C-reactive protein (p = 0.042) and a lower rate of proteinuria (p = 0.031) than non-carriers. After multivariate adjustment, mutation carriers had lower serum CRP levels than non-carriers (p = 0.031. Patients with mutation also had a greater chance of recovery from hypertension after operation (p = 0.005). A high incidence of somatic mutations in APA was identified in the Taiwanese population. Mutation-carriers had lower CRP levels and a higher rate of cure of hypertension after adrenalectomy. This raises the possibility of using mutation screening as a tool in predicting long-term outcome after adrenalectomy.
- Subjects
HYPERALDOSTERONISM; SOMATIC mutation; ADENOMA; TAIWANESE people; ADRENALECTOMY; HEALTH
- Publication
Scientific Reports, 2015, p11396
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep11396