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- Title
Endocrine Fibroblast Growth Factors in Relation to Stress Signaling.
- Authors
Shimizu, Makoto; Sato, Ryuichiro
- Abstract
Fibroblast growth factors (FGFs) play important roles in various growth signaling processes, including proliferation, development, and differentiation. Endocrine FGFs, i.e., atypical FGFs, including FGF15/19, FGF21, and FGF23, function as endocrine hormones that regulate energy metabolism. Nutritional status is known to regulate the expression of endocrine FGFs through nuclear hormone receptors. The increased expression of endocrine FGFs regulates energy metabolism processes, such as fatty acid metabolism and glucose metabolism. Recently, a relationship was found between the FGF19 subfamily and stress signaling during stresses such as endoplasmic reticulum stress and oxidative stress. This review focuses on endocrine FGFs and the recent progress in FGF studies in relation to stress signaling. In addition, the relevance of the stress–FGF pathway to disease and human health is discussed.
- Subjects
FIBROBLAST growth factors; NUCLEAR receptors (Biochemistry); ENERGY metabolism; OXIDATIVE stress; GLUCOSE metabolism; ENDOPLASMIC reticulum
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 3, p505
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11030505