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- Title
Expression and Function of ZEB1 in the Cornea.
- Authors
Zhang, Yingnan; Liu, Xiao; Liang, Wei; Dean, Douglas C.; Zhang, Lijun; Liu, Yongqing; Ljubimov, Alexander V.; Karamichos, Dimitrios
- Abstract
ZEB1 is an important transcription factor for epithelial to mesenchymal transition (EMT) and in the regulation of cell differentiation and transformation. In the cornea, ZEB1 presents in all three layers: the epithelium, the stroma and the endothelium. Mutations of ZEB1 have been linked to multiple corneal genetic defects, particularly to the corneal dystrophies including keratoconus (KD), Fuchs endothelial corneal dystrophy (FECD), and posterior polymorphous corneal dystrophy (PPCD). Accumulating evidence indicates that dysfunction of ZEB1 may affect corneal stem cell homeostasis, and cause corneal cell apoptosis, stromal fibrosis, angiogenesis, squamous metaplasia. Understanding how ZEB1 regulates the initiation and progression of these disorders will help us in targeting ZEB1 for potential avenues to generate therapeutics to treat various ZEB1-related disorders.
- Subjects
EPITHELIAL-mesenchymal transition; CORNEAL dystrophies; CORNEA; DYSTROPHY; CELL transformation; HOMEOSTASIS
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 4, p925
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10040925