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- Title
Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer.
- Authors
Baj, Jacek; Korona-Głowniak, Izabela; Forma, Alicja; Maani, Amr; Sitarz, Elżbieta; Rahnama-Hezavah, Mansur; Radzikowska, Elżbieta; Portincasa, Piero
- Abstract
Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of the world's population. Approximately 20% of the infected patients develop gastric ulcers or neoplastic changes in the gastric stroma. An infection also leads to the progression of epithelial–mesenchymal transition within gastric tissue, increasing the probability of gastric cancer development. This paper aims to review the role of H. pylori and its virulence factors in epithelial–mesenchymal transition associated with malignant transformation within the gastric stroma. The reviewed factors included: CagA (cytotoxin-associated gene A) along with induction of cancer stem-cell properties and interaction with YAP (Yes-associated protein pathway), tumor necrosis factor α-inducing protein, Lpp20 lipoprotein, Afadin protein, penicillin-binding protein 1A, microRNA-29a-3p, programmed cell death protein 4, lysosomal-associated protein transmembrane 4β, cancer-associated fibroblasts, heparin-binding epidermal growth factor (HB-EGF), matrix metalloproteinase-7 (MMP-7), and cancer stem cells (CSCs). The review summarizes the most recent findings, providing insight into potential molecular targets and new treatment strategies for gastric cancer.
- Subjects
STOMACH cancer; TUMOR microenvironment; EPIDERMAL growth factor; TUMOR necrosis factors; MEMBRANE proteins; LYSOSOMES
- Publication
Cells (2073-4409), 2020, Vol 9, Issue 4, p1055
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells9041055