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- Title
Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium–hydrogen exchange in hypertensive patients with Type 2 diabetes.
- Authors
Pikilidou, M. I.; Lasaridis, A. N.; Sarafidis, P. A.; Befani, C. D.; Koliakos, G. G.; Tziolas, I. M.; Kazakos, K. A.; Yovos, J. G.; Nilsson, P. M.
- Abstract
Aims/hypothesis To investigate the effect of oral calcium (Ca2+) supplementation on insulin sensitivity measured by the euglycaemic hyperinsulinaemic clamp, intraplatelet cationic concentration of Ca2+ ([Ca2+]i) and the transmembrane sodium–hydrogen exchanger (NHE) activity in erythrocytes in subjects with Type 2 diabetes and hypertension. Patients and methods In this parallel randomized controlled single-blinded trial, 31 patients were allocated to receive either 1500 mg of Ca2+ orally, daily ( n = 15) or no treatment ( n = 16) for 8 weeks. At baseline and at the end of the 8-week period insulin sensitivity, [Ca2+]i and the first isoform of NHE (NHE-1) activity were measured. Results At the end of the study, subjects who received Ca2+ supplementation showed higher insulin sensitivity (Δ M-value 0.32 ± 0.5 mmol/min P < 0.05) and lower [Ca2+]i (125.0 ± 24.7 to 80.4 ± 10.6 nmol/l, P < 0.05, mean ± sem) and NHE-1 activity (79.5 ± 10.0 to 52.1 ± 6.4 mmol Na/l red cell/h, P < 0.05). None of the above parameters were changed in the control group. Simple regression analysis demonstrated the change in [Ca2+]i significantly determined insulin sensitivity change (β = −0.36, P < 0.05). Conclusions/interpretation Oral Ca2+ supplementation improves insulin sensitivity in patients with Type 2 diabetes and hypertension. These changes are likely to be mediated by changes in intracellular ionic Ca2+. NHE-1 activity was also reduced after Ca2+ supplementation but its role in insulin sensitivity requires further investigation.
- Subjects
PHYSIOLOGICAL effects of calcium; TYPE 2 diabetes; CALCIUM in the body; HYPERTENSION; PHYSIOLOGICAL effects of insulin; RANDOMIZED controlled trials
- Publication
Diabetic Medicine, 2009, Vol 26, Issue 3, p211
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2009.02673.x