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- Title
Prostate Cancer Stem Cells and Nanotechnology: A Focus on Wnt Signaling.
- Authors
Wei Qin; Yongjiang Zheng; Bin-Zhi Qian; Meng Zhao
- Abstract
Prostate cancer is the most common cancer among men worldwide. However, current treatments for prostate cancer patients in advanced stage often fail because of relapse. Prostate cancer stem cells (PCSCs) are resistant to most standard therapies, and are considered to be a major mechanism of cancer metastasis and recurrence. In this review, we summarized current understanding of PCSCs and their self-renewal signaling pathways with a specific focus on Wnt signaling. Although multiple Wnt inhibitors have been developed to target PCSCs, their application is still limited by inefficient delivery and toxicity in vivo. Recently, nanotechnology has opened a new avenue for cancer drug delivery, which significantly increases specificity and reduces toxicity. These nanotechnology-based drug delivery methods showed great potential in targeting PCSCs. Here, we summarized current advancement of nanotechnologybased therapeutic strategies for targeting PCSCs and highlighted the challenges and perspectives in designing future therapies to eliminate PCSCs.
- Subjects
PROSTATE cancer treatment; NANOTECHNOLOGY; WNT signal transduction
- Publication
Frontiers in Pharmacology, 2017, Vol 8, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2017.00153