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- Title
The role of B cells in COVID-19 infection and vaccination.
- Authors
Shiru Chen; Fei Guan; Candotti, Fabio; Benlagha, Kamel; Saraiva Camara, Niels Olsen; Herrada, Andres A.; James, Louisa K.; Jiahui Lei; Miller, Heather; Masato Kubo; Qin Ning; Chaohong Liu
- Abstract
B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARSCoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.
- Subjects
B cells; COVID-19; MEDICAL personnel; COVID-19 vaccines; HUMORAL immunity
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.988536