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- Title
PEG<sub>600</sub>-Carboxylates as Efficient Reusable Reaction Media and Acylating Agents for the Resolution of sec-Alcohols.
- Authors
Monteiro, Carlos M.; Lourenço, Nuno M. T.; Ferreira, Frederico C.; Afonso, Carlos A. M.
- Abstract
Herein is presented a simple, attractive, and reusable methodology for one-pot resolution/separation of free sec-alcohols with enantiomeric excess (ee) values over 90% by the combination of sustainable acylating agents/solvents (polyethylene glycol derivatives) and an easily available and common biocatalyst (Candida antarctica lipase B, or CAL B) under irreversible conditions, along with a separation process by extraction or distillation. A scale-up reaction was carried out with the Fluoxetine precursor with ee values close to 90% for the R enantiomer.
- Subjects
SOLVENTS; POLYETHYLENE glycol; SEPARATION technology equipment; CHEMICAL derivatives; ENZYMES; DISTILLATION; ENANTIOMERS
- Publication
ChemPlusChem, 2015, Vol 80, Issue 1, p42
- ISSN
2192-6506
- Publication type
Article
- DOI
10.1002/cplu.201402049