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- Title
Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas.
- Authors
YUAN YUE; YUMIN YANG; LEI SHI; ZUOREN WANG
- Abstract
The aim of this study was to investigate the expression and significance of a disintegrin and metalloproteinase 10 (ADAM10), epidermal growth factor receptor (EGFR) and E-cadherin protein in hepatocellular carcinomas. The expression levels of ADAM10, EGFR and E-cadherin were analyzed in 40 cases of hepatocellular carcinoma using immunohistochemistry and quantitative polymerase chain reaction (qPCR). The expression levels of ADAM10, EGFR and E-cadherin were significantly correlated with portal vein thrombosis, intrahepatic metastasis, differentiation degree and tumor size (P<0.05). In hepatocellular carcinoma, the expression levels of ADAM10 and EGFR were increased and the levels of E-cadherin were decreased compared with those in the adjacent tissues. The elevated expression levels of ADAM10 and EGFR may be associated with the malignancy of the tumors. E-cadherin expression is negatively correlated with the degree of malignancy. The detection of ADAM10, EGFR and E-cadherin expression levels may contribute to an understanding of the oncogenesis and development of hepatocellular carcinomas.
- Subjects
LIVER cancer; LIVER cancer patients; EPIDERMAL growth factor receptors regulation; PROTEIN-tyrosine kinase regulation; METALLOPROTEINASE regulation; CADHERINS; CELL adhesion molecules; DIAGNOSTIC use of polymerase chain reaction
- Publication
Experimental & Therapeutic Medicine, 2013, Vol 6, Issue 6, p1380
- ISSN
1792-0981
- Publication type
Article
- DOI
10.3892/etm.2013.1340