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- Title
Characterizing 1-year development of cervical cord atrophy across different MS phenotypes: A voxel-wise, multicentre analysis.
- Authors
Valsasina, Paola; Gobbi, Claudio; Zecca, Chiara; Rovira, Alex; Sastre-Garriga, Jaume; Kearney, Hugh; Yiannakas, Marios; Matthews, Lucy; Palace, Jacqueline; Gallo, Antonio; Bisecco, Alvino; Gass, Achim; Eisele, Philipp; Filippi, Massimo; Rocca, Maria A; Barkhof, Frederik; Ciccarelli, Olga; De Stefano, Nicola; Enzinger, Christian; Gasperini, Claudio
- Abstract
Background: Spatio-temporal evolution of cord atrophy in multiple sclerosis (MS) has not been investigated yet. Objective: To evaluate voxel-wise distribution and 1-year changes of cervical cord atrophy in a multicentre MS cohort. Methods: Baseline and 1-year 3D T1-weighted cervical cord scans and clinical evaluations of 54 healthy controls (HC) and 113 MS patients (14 clinically isolated syndromes (CIS), 77 relapsing-remitting (RR), 22 progressive (P)) were used to investigate voxel-wise cord volume loss in patients versus HC, 1-year volume changes and clinical correlations (SPM12). Results: MS patients exhibited baseline cord atrophy versus HC at anterior and posterior/lateral C1/C2 and C4–C6 (p < 0.05, corrected). While CIS patients showed baseline volume increase at C4 versus HC (p < 0.001, uncorrected), RRMS exhibited posterior/lateral C1/C2 atrophy versus CIS, and PMS showed widespread cord atrophy versus RRMS (p < 0.05, corrected). At 1 year, 13 patients had clinically worsened. Cord atrophy progressed in MS, driven by RRMS, at posterior/lateral C2 and C3–C6 (p < 0.05, corrected). CIS patients showed no volume changes, while PMS showed circumscribed atrophy progression. Baseline cord atrophy at posterior/lateral C1/C2 and C3–C6 correlated with concomitant and 1-year disability (r = −0.40/–0.62, p < 0.05, corrected). Conclusions: Voxel-wise analysis characterized spinal cord neurodegeneration over 1 year across MS phenotypes and helped to explain baseline and 1-year disability.
- Subjects
CERVICAL cord; ATROPHY; SPATIOTEMPORAL processes; SPINAL cord; MULTIPLE sclerosis
- Publication
Multiple Sclerosis Journal, 2022, Vol 28, Issue 6, p885
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585211045545