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- Title
Toxic epidermal necrolysis induced by methazolamide in a Chinese- Korean man carrying HLA- B*59:01.
- Authors
Shu, Chang; Shu, Dan; Tie, Duerna; Yu, Mengqing; Zhang, Rui; Wang, Tong; Dong, Qi; Sun, Qiuning; Mao, Xuming; Yan, Yan
- Abstract
Background Methazolamide is used to lower intraocular pressure in patients with glaucoma. Stevens- Johnson syndrome ( SJS) and toxic epidermal necrolysis ( TEN) associated with methazolamide treatment have been diagnosed in Korean, Japanese, and Japanese- American patients. According to recent research, the human leukocyte antigen ( HLA) allele HLA-B*59:01 is strongly linked to SJS/ TEN associated with methazolamide treatment. Objective A patient of Chinese- Korean ethnicity was diagnosed with TEN associated with methazolamide treatment. The purpose of this study was to examine the potential genetic basis of this disease. Methods A polymerase chain reaction sequence-specific primer ( PCR- SSP) typing system was used to genotype this patient's peripheral blood DNA for HLA- B*59. Results The genotype HLA- B*59:01 was detected in the patient. Conclusions This study demonstrates the genotype of HLA- B*59:01 in a patient with TEN associated with methazolamide treatment and thus supports the possible correlation between genetic background and methazolamide-associated SJS/ TEN.
- Subjects
GLAUCOMA; HLA histocompatibility antigens; STEVENS-Johnson Syndrome; TOXIC epidermal necrolysis; POLYMERASE chain reaction
- Publication
International Journal of Dermatology, 2015, Vol 54, Issue 11, p1242
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.12651