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- Title
Glycemic Effectiveness of Metformin-Based Dual-Combination Therapies with Sulphonylurea, Pioglitazone, or DPP4-Inhibitor in Drug-Naïve Korean Type 2 Diabetic Patients.
- Authors
Young Ki Lee; Sun Ok Song; Kwang Joon Kim; Yongin Cho; Younjeong Choi; Yujung Yun; Byung-Wan Lee; Eun-Seok Kang; Bong Soo Cha; Hyun Chul Lee
- Abstract
Background: This study compared the glycemic effectiveness of three metformin-based dual therapies according to baseline hemoglobin Aic (HbAlc) to evaluate the appropriateness of the guideline enforced by the National Health Insurance Corporation of Korea for initial medication of type 2 diabetes (T2D). Methods: This prospective observational study was conducted across 24 weeks for drug-naïve Korean T2D patients with HbAlc greater than 7.5%. Subjects were first divided into three groups based on the agent combined with metformin (group 1, gliclazidemodified release or glimepiride; group 2, pioglitazone; group 3, sitagliptin). Subjects were also classified into three categories according to baseline HbAlc (category I, 7.5% ≤HbAlc <9.0%; category II, 9.0% ≤HbAlc <11.0%; category III, 11.0% ≤ HbAlc). Results: Among 116 subjects, 99 subjects completed the study, with 88 subjects maintaining the initial medication. While each of the metformin-based dual therapies showed a significant decrease in HbAlc (group 1, 8.9% to 6.4%; group 2, 9.0% to 6.6%; group 3, 9.3% to 6.3%; P<0.001 for each), there was no significant difference in the magnitude of HbAlc change among the groups. While the three HbAlc categories showed significantly different baseline HbAlc levels (8.2% vs. 9.9% vs. 11.9%; P<0.001), endpoint HbAlc was not different (6.4% vs. 6.6% vs. 6.0%; P=0.051). Conclusion: The three dual therapies using a combination of metformin and either sulfonylurea, pioglitazone, or sitagliptin showed similar glycemic effectiveness among drug-naïve Korean T2D patients. In addition, these regimens were similarly effective across a wide range of baseline HbAlc levels.
- Subjects
GLYCEMIC index; CARBOHYDRATE content of food; METFORMIN; GUANIDINES; UREA
- Publication
Diabetes & Metabolism Journal, 2013, Vol 37, Issue 6, p465
- ISSN
2233-6079
- Publication type
Article
- DOI
10.4093/dmj.2013.37.6.465