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- Title
A Case of von Hippel-Lindau Disease with Colorectal Adenocarcinoma, Renal Cell Carcinoma and Hemangioblastomas.
- Authors
Su Jin Heo; Choong-kun Lee; Kyu Yeon Hahn; Gyuri Kim; Hyuk Hur; Sung Hoon Choi; Kyung Seok Han; Arthur Cho; Minkyu Jung
- Abstract
von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome associated with mutations of the VHL tumor suppressor gene located on chromosome 3p25. The loss of functional VHL protein contributes to tumorigenesis. This condition is characterized by development of benign and malignant tumors in the central nervous system (CNS) and the internal organs, including kidney, adrenal gland, and pancreas. We herein describe the case of a 74-year-old man carrying the VHL gene mutation who was affected by simultaneous colorectal adenocarcinoma, renal clear cell carcinoma, and hemangioblastomas of CNS.
- Subjects
VON Hippel-Lindau disease; COLON cancer; RENAL cell carcinoma; HEMANGIOBLASTOMAS; ADENOCARCINOMA; GENETIC mutation
- Publication
Cancer Research & Treatment, 2016, Vol 48, Issue 1, p409
- ISSN
1598-2998
- Publication type
Case Study
- DOI
10.4143/crt.2014.299