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- Title
COMPARATIVE STUDY ON THE ORAL MICROBIOME IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND ITS IMPACT ON SYSTEMIC INFLAMMATION.
- Authors
Babu, G. Ranjith; P., Anand; Reddy, P. Vamsavardhana; S., Sharath Chand; Augustine, Sabu; Velangupara, Sruthy
- Abstract
Background: Chronic Kidney Disease (CKD) is linked to systemic inflammation, which may be influenced by the oral microbiome. This study aimed to compare the oral microbiome of CKD patients with that of healthy individuals and examine its impact on systemic inflammation. Materials and Methods: The study included 100 participants: 50 CKD patients and 50 healthy controls. Microbial diversity indices, dominant phyla distribution, and key genera abundances were assessed using high-throughput sequencing. Systemic inflammation markers, such as C-Reactive Protein (CRP), Interleukin-6 (IL-6), and Tumor Necrosis Factor-alpha (TNF-α), were measured. Correlation analyses were performed to explore the relationships between microbial abundances and inflammation markers. Results: CKD patients showed significantly lower microbial diversity compared to healthy controls (Shannon Index: 3.2 ± 0.5 vs. 4.1 ± 0.6; Simpson Index: 0.76 ± 0.1 vs. 0.84 ± 0.1). Dominant phyla in CKD patients included Firmicutes (45%), Proteobacteria (30%), Bacteroidetes (15%), and Actinobacteria (10%), while healthy controls had Firmicutes (50%), Bacteroidetes (25%), Actinobacteria (15%), and Proteobacteria (10%). Notable genera differences included higher abundances of Streptococcus and Neisseria in CKD patients and higher abundances of Lactobacillus and Prevotella in healthy controls. Systemic inflammation markers were elevated in CKD patients (CRP: 6.2 mg/L ± 1.2 vs. 2.1 mg/L ± 0.8; IL-6: 8.5 pg/mL ± 1.5 vs. 3.2 pg/mL ± 0.9; TNF-α: 12.4 pg/mL ± 2.1 vs. 5.3 pg/mL ± 1.4). Positive correlation was found between Streptococcus abundance and CRP levels (r = 0.72, p < 0.001), and a negative correlation between Lactobacillus abundance and IL-6 levels (r = -0.65, p < 0.01). Conclusion: CKD patients exhibit altered oral microbiome profiles and increased systemic inflammation. These findings suggest a connection between oral microbiome imbalance and systemic inflammation in CKD, highlighting the importance of further research on potential therapeutic approaches.
- Subjects
TUMOR necrosis factors; CHRONIC kidney failure; MICROBIAL diversity; C-reactive protein; NUCLEOTIDE sequencing
- Publication
International Journal of Medicine & Public Health, 2024, Vol 14, Issue 3, p166
- ISSN
2230-8598
- Publication type
Article
- DOI
10.70034/ijmedph.2024.3.29