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- Title
Pancreatic cancer cachexia: a review of mechanisms and therapeutics.
- Authors
Tan, Carlyn R.; Yaffee, Patrick M.; Jamil, Laith H.; Lo, Simon K.; Nissen, Nicholas; Pandol, Stephen J.; Tuli, Richard; Hendifar, Andrew E.
- Abstract
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge. Pancreatic cancer cachexia is a multifactorial syndrome characterized by uncompensated adipose tissue and skeletal muscle loss in the setting of anorexia that leads to progressive functional impairment. This paper will review the current concepts of pancreatic cancer cachexia, its assessment and pathophysiology as well as current and future treatments. The successful management of pancreatic cancer cachexia will likely require a multimodal approach that includes nutritional support and combination pharmaceutical interventions.
- Subjects
CACHEXIA; PANCREATIC cancer; ANOREXIA nervosa; METABOLISM; APPETITE disorders
- Publication
Frontiers in Physiology, 2014, Vol 5, p1
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2014.00088