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- Title
Monosodium glutamate modulates the circadian rhythms of biochemical variables and behavioral activity in rats under constant light.
- Authors
Kumaravel, Palanisamy; Subash, Selvaraju; Seethalakshmi, Krishnamoorthy Swarnam; Murugan, Natarajan; Yuvarajan, Ragunathan; Subramanian, Perumal
- Abstract
Introduction: Suprachiasmatic nuclei (SCN) contained a variety of neurotransmitters and neuropeptides, and many of them could influence the activities of the circadian pacemaker. Glutamate was the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and in SCN. Materials and Methods: Monosodium glutamate (MSG) (50 mg / kg body weight) was administered subcutaneously for 60 days to Wistar rats; open-field behavioral activity and 24-hour rhythms of glucose, cholesterol, total protein, phospholipids, aspartate transaminase (AST), and alkaline phosphatase (ALT) were studied under conditions of constant light (LL). Results: An open-field behavioral test showed that peripheral movement, central movement, rearing and grooming, were significantly decreased in LL, MSG and LL (MSG-treated) rats when compared with the control rats. The study revealed that the acrophase, amplitude, and mesor values of the glucose, protein, lipid profile, and liver marker enzymes of these rhythms were found to be altered in the experimental group rats when compared with the control rats. Conclusion: Monosodium glutamate, under constant light, modulated the circadian rhythms of lipid profiles and liver marker enzymes, which could be due to glutamate conveying the photic information to the SCN.
- Subjects
SUPRACHIASMATIC nucleus; NEUROTRANSMITTERS; NEUROPEPTIDES; CIRCADIAN rhythms; GLUTAMIC acid; CENTRAL nervous system; LABORATORY rats; ENZYMES
- Publication
International Journal of Nutrition, Pharmacology, Neurological Diseases, 2012, Vol 2, Issue 3, p251
- ISSN
2231-0738
- Publication type
Article