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- Title
Fiber-Optic Raman Spectrum Sensor for Fast Diagnosis of Esophageal Cancer.
- Authors
Dai, Jianhua; He, Xiu; Li, Zhuoyue; Li, Kang; Yang, Tingting; Ran, Zengling; Yin, Lijian; Chen, Yao; Zou, Xiang; Fang, Dianchun; Peng, Guiyong
- Abstract
A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination. The system contains a 785 nm exciting laser, a Raman fiber-optic probe with 7 large core fibers and a focus lens, and a highly sensitive spectrum meter. The Raman spectrum of the tissue could be obtained within 1 second by using such a system. A signal baseline removal and denoising technology is used to improve the signal quality. A novel signal feature extraction method for differentiating the normal and esophageal cancer tissues is proposed, based on the differences in half-height width (HHW) in 1200 cm‒1 to 1400 cm‒1 frequency band and the ratios of the spectral integral energy between 1600 cm‒1 − 1700 cm‒1 and 1500 cm‒1 − 1600 cm‒1 band. It shows a high specificity and effectivity for the diagnosis of esophageal cancer.
- Subjects
ESOPHAGEAL cancer; CANCER diagnosis; EARLY detection of cancer; DIAGNOSTIC imaging; RAMAN spectra; RAMAN scattering
- Publication
Photonic Sensors, 2019, Vol 9, Issue 1, p53
- ISSN
1674-9251
- Publication type
Article
- DOI
10.1007/s13320-018-0516-7