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- Title
EGCG treats ICH via up-regulating miR-137-3p and inhibiting Parthanatos.
- Authors
Jianjun Wang; Xuejun Kuang; Zhao Peng; Conghui Li; Chengwu Guo; Xi Fu; Junhong Wu; Yang Luo; Xiaolin Rao; Xiangjuan Zhou; Bin Huang; Weijun Tang; Yinjuan Tang
- Abstract
Intracranial hemorrhage (ICH) causes high mortality and disability without effective treatment in the clinical setting. (−)-Epigallocatechin-3-gallate (EGCG) exerts an essential role in the central nervous system and offers a promising therapeutic agent for the treatment of oxidative damage-related diseases. MiR-137 can inhibit the oxidative stress and apoptosis to attenuate neuronal injury. However, the role of EGCG in regulating miR-137- 3p and neuronal Parthanatos remains to be unclear. In the present study, we build the ICH mice model to investigate the antioxidant effects of EGCG via upregulating miR-137-3p and inhibiting neuronal Parthanatos. We revealed that EGCG upregulated miR-137-3p and inhibited neuronal Parthanatos, and promoted the functional recovery, alleviated ICH-induced brain injury, and reduced oxidative stress in mice following ICH. However, following the inhibition of miR-137-3p and activation of Parthanatos, EGCG was unable to exert neuroprotective roles. These combined results suggest that EGCG may upregulate miR-137-3p and inhibit neuronal Parthanatos to accelerate functional recovery in mice after ICH, laying the foundation for EGCG to be a novel strategy for the treatment of neuronal injuries related to Parthanatos.
- Publication
Translational Neuroscience, 2020, Vol 11, Issue 1, p371
- ISSN
2081-3856
- Publication type
Article
- DOI
10.1515/tnsci-2020-0143