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- Title
In long bacterial cells, the Min system can act off‐center.
- Authors
MacCready, Joshua S.; Vecchiarelli, Anthony G.
- Abstract
Summary: In many rod‐shaped bacteria, the Min system is well‐known for generating a cell‐pole to cell‐pole standing wave oscillation with a single node at mid‐cell to align cell division. In filamentous E. coli cells, the single‐node standing wave transitions into a multi‐nodal oscillation. These multi‐nodal dynamics have largely been treated simply as an interesting byproduct of artificially elongated cells. However, a recent in vivo study by Muraleedharan et al. shows how multi‐nodal Min dynamics are used to align non‐mid‐cell divisions in the elongated swarmer cells of Vibrio parahaemolyticus. The authors propose a model where the combined actions of cell‐length dependent Min dynamics, in concert with nucleoid occlusion along the cell length and regulation of FtsZ levels ensures Z ring formation and complete chromosome segregation at a single off‐center position. By limiting the number of cell division events to one per cell at an off‐center position, long swarmer cells are preserved within a multiplying population. The findings unveil an elegant mechanism of cell‐division regulation by the Min system that allows long swarmer cells to divide without the need to ‘dedifferentiate’.
- Subjects
BACILLUS (Bacteria); BACILLUS genetics; BACTERIAL chromosomes; CHROMOSOME segregation; OSCILLATIONS; BACTERIAL genetics; PHYSIOLOGY
- Publication
Molecular Microbiology, 2018, Vol 109, Issue 3, p268
- ISSN
0950-382X
- Publication type
Article
- DOI
10.1111/mmi.13995