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- Title
Recurrent gastrointestinal bleeding in a patient with Heyde syndrome with elevated factor VIII levels: A case report.
- Authors
Al-Radaideh, Omar; Farouji, Iyad; Abed, Hossam; Shaaban, Hamid
- Abstract
Heyde syndrome is the association between gastrointestinal (GI) bleeding from intestinal angiodysplasia (IA) and aortic stenosis (AS). Although the course of disease progression that links AS and GI bleeding has not been determined, overlaps among AS, intestinal dysplasia, and acquired von Willebrand's syndrome is thought to result in GI bleeding. Proper repair of the aortic valve can result in significant improvement of GI bleeding and its recurrence. Herein, we are reporting this rare case, in which a patient with moderate AS on echocardiogram presents with recurrent GI bleeding from multiple IA in the setting of elevated factor VIII levels, to propose a theory that angiodysplasia could potentially develop due to intermittent, recurrent low-grade obstruction of submucosal veins at the level of the muscularis propria secondary to venous thrombosis related to elevated factor VIII levels.
- Subjects
BLOOD coagulation factor VIII; GASTROINTESTINAL hemorrhage; VON Willebrand disease; AORTIC stenosis; SYNDROMES; AORTIC valve; VENOUS thrombosis
- Publication
International Journal of Critical Illness & Injury Science, 2021, Vol 11, Issue 4, p253
- ISSN
2229-5151
- Publication type
Article
- DOI
10.4103/IJCIIS.IJCIIS_151_20