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- Title
Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient.
- Authors
Lee, Rami; Kim, Ji-Hun; Hwang, Hongik; Rhim, Hyewhon; Hwang, Sung-Hee; Cho, Ik-Hyun; Kim, Do-Geun; Kim, Hyoung-Chun; Nah, Seung-Yeol
- Abstract
Ginseng is one of the traditional herbal medicines for tonic. Gintonin is a new material derived from white/red ginseng and its lysophosphatidic acids (LPAs) play as a ligand for G protein-coupled LPA receptors. Korean red ginseng marc (KRGM) is a by-product after the KRG processes. We developed a low-cost/high-efficiency method for KRGM gintonin production. We further studied the KRGM gintonin-mediated anti-skin aging effects under UVB exposure using human dermal fibroblasts (HDFs). KRGM gintonin yield is about 8%. KRGM gintonin contains a high amount of LPA C18:2, lysophosphatidylcholine (LPC), and phosphatidylcholine (PC), which is similar to white ginseng gintonin. KRGM gintonin induced [Ca2+]i transient via LPA1/3 receptors and increased cell viability/proliferation under UVB exposure. The underlying mechanisms of these results are associated with the antioxidant action of KRGM gintonin. KRGM gintonin attenuated UVB-induced cell senescence by inhibiting cellular β-galactosidase overexpression and facilitated wound healing. These results indicate that KRGM can be a novel bioresource of KRGM gintonin, which can be industrially utilized as new material for skin nutrition and/or skin healthcare.
- Subjects
WOUND healing; COSMETICS; IN vitro studies; FIBROBLASTS; SKIN care; NUTRITIONAL requirements; CELL receptors; ANTIOXIDANTS; QUANTITATIVE research; CELL survival; GENE expression; SKIN aging; MASS spectrometry; RESEARCH funding; GINSENG
- Publication
Nutrients, 2023, Vol 15, Issue 11, p2574
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15112574