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- Title
Effects of Microecological Regulators on Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials.
- Authors
Wu, Tong; Li, Yanhong; Wu, Yinlan; Liang, Xiuping; Zhou, Yu; Liao, Zehui; Wen, Ji; Cheng, Lu; Luo, Yubin; Liu, Yi
- Abstract
In this study, the available data from published randomized, controlled trials (RCTs) of the use of intestinal microecological regulators as adjuvant therapies to relieve the disease activity of rheumatoid arthritis (RA) are systematically compared. An English literature search was performed using PubMed, Embase, Scopus, Web of Science and the Cochrane Central Registry of Controlled Trials and supplemented by hand searching reference lists. Three independent reviewers screened and assessed the quality of the studies. Among the 2355 citations identified, 12 RCTs were included. All data were pooled using a mean difference (MD) with a 95% CI. The disease activity score (DAS) showed a significant improvement following microecological regulators treatment (MD (95% CI) of −1.01 (−1.81, −0.2)). A borderline significant reduction in the health assessment questionnaire (HAQ) scores was observed (MD (95% CI) of −0.11 (−0.21, −0.02)). We also confirmed the known effects of probiotics on inflammatory parameters such as the C-reactive protein (CRP) (MD −1.78 (95% CI −2.90, −0.66)) and L-1β (MD −7.26 (95% CI −13.03, −1.50)). No significant impact on visual analogue scale (VAS) of pain and erythrocyte sedimentation rate (ESR) reduction was observed. Intestinal microecological regulators supplementation could decrease RA activity with a significant effect on DAS28, HAQ and inflammatory cytokines. Nevertheless, these findings need further confirmation in large clinical studies with greater consideration of the confounding variables of age, disease duration, and individual medication regimens.
- Subjects
ONLINE information services; MEDICAL databases; C-reactive protein; CYTOKINES; PREBIOTICS; META-analysis; MEDICAL information storage &; retrieval systems; CONFIDENCE intervals; SYSTEMATIC reviews; VISUAL analog scale; PROBIOTICS; RANDOMIZED controlled trials; RHEUMATOID arthritis; DISEASE duration; RESEARCH funding; DESCRIPTIVE statistics; QUESTIONNAIRES; BLOOD sedimentation; SYNBIOTICS; MEDLINE
- Publication
Nutrients, 2023, Vol 15, Issue 5, p1102
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15051102